2-(1-(((9H-fluoren-9-yl)Methoxy)carbonyl)azetidin-3-yl)acetic acid
1-Fmoc-3-carboxymethyl-azetidine
CAS: 959236-89-6
Molecular Formula: C20H19NO4
2-(1-(((9H-fluoren-9-yl)Methoxy)carbonyl)azetidin-3-yl)acetic acid - Names and Identifiers
2-(1-(((9H-fluoren-9-yl)Methoxy)carbonyl)azetidin-3-yl)acetic acid - Physico-chemical Properties
| Molecular Formula | C20H19NO4 |
| Molar Mass | 337.37 |
2-(1-(((9H-fluoren-9-yl)Methoxy)carbonyl)azetidin-3-yl)acetic acid - Introduction
It is an organic compound with a molecular formula of C21H21NO4, which is often used as a protecting group in solid phase synthesis.
Nature:
It is a white to yellowish solid, soluble in organic solvents such as dimethyl sulfoxide, methanol and chloroform. It is stable in the air, but avoid prolonged exposure to sunlight.
Use:
It is often used as a protecting group to protect the side chains of amino acids during solid phase synthesis in peptide synthesis. By attaching it to the side chain of an amino acid, side reactions can be prevented from occurring during synthesis. After completion of the synthesis, the protecting group can be removed by an appropriate method to reduce the activity of the amino acid.
Preparation Method: The preparation method of
is more complicated and generally needs to be obtained through a multi-step reaction. Specifically, usually starting from azetidine, Fmoc protecting group is attached to the N-9 position of azetidine through a multi-step reaction, and then synthesized by acidolysis reaction.
Safety Information:
It is relatively stable under general operating conditions, but it still needs to be operated in a well-ventilated laboratory. It may cause irritation to the skin, eyes and respiratory tract, so it is necessary to wear appropriate personal protective equipment, such as laboratory gloves, goggles and laboratory coats. During use, direct contact with the skin and inhalation of its dust should be avoided. In case of contact, rinse immediately with plenty of water. Also, properly store and dispose of the compound to avoid mixing with other chemicals or contact with organics. Specific safety operation instructions should refer to the safety data sheet provided by the supplier.
Nature:
It is a white to yellowish solid, soluble in organic solvents such as dimethyl sulfoxide, methanol and chloroform. It is stable in the air, but avoid prolonged exposure to sunlight.
Use:
It is often used as a protecting group to protect the side chains of amino acids during solid phase synthesis in peptide synthesis. By attaching it to the side chain of an amino acid, side reactions can be prevented from occurring during synthesis. After completion of the synthesis, the protecting group can be removed by an appropriate method to reduce the activity of the amino acid.
Preparation Method: The preparation method of
is more complicated and generally needs to be obtained through a multi-step reaction. Specifically, usually starting from azetidine, Fmoc protecting group is attached to the N-9 position of azetidine through a multi-step reaction, and then synthesized by acidolysis reaction.
Safety Information:
It is relatively stable under general operating conditions, but it still needs to be operated in a well-ventilated laboratory. It may cause irritation to the skin, eyes and respiratory tract, so it is necessary to wear appropriate personal protective equipment, such as laboratory gloves, goggles and laboratory coats. During use, direct contact with the skin and inhalation of its dust should be avoided. In case of contact, rinse immediately with plenty of water. Also, properly store and dispose of the compound to avoid mixing with other chemicals or contact with organics. Specific safety operation instructions should refer to the safety data sheet provided by the supplier.
Last Update：2024-04-10 22:29:15
